Microvascular oxygen tension in the rat mesentery

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Microvascular oxygen tension in the rat mesentery.

Longitudinal Po(2) profiles in the microvasculature of the rat mesentery were studied using a novel phosphorescence quenching microscopy technique that minimizes the accumulated photoconsumption of oxygen by the method. Intravascular oxygen tension (Po(2), in mmHg) and vessel diameter (d, in microm) were measured in mesenteric microvessels (n = 204) of seven anesthetized rats (275 g). The excit...

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Microvascular and tissue oxygen gradients in the rat mesentery.

One of the most important functions of the blood circulation is O2 delivery to the tissue. This process occurs primarily in microvessels that also regulate blood flow and are the site of many metabolic processes that require O2. We measured the intraluminal and perivascular pO2 in rat mesenteric arterioles in vivo by using noninvasive phosphorescence quenching microscopy. From these measurement...

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Oxygen phosphorescence quenching was used to measure tissue Po(2) of lymphatic vessels of 43.6 +/- 23.1 microm (mean +/- SD) diameter in tissue locations of the rat mesentery classified according to anatomic location. Lymph and adipose tissue Po(2) were 20.6 +/- 9.1 and 34.1 +/- 7.8 mmHg, respectively, with the difference being statistically significant. Rare microlymphatic vessels in connectiv...

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Microvascular responses to alterations in oxygen tension.

The changes in microvascular diameter and perivascular oxygen tension resulting from alterations in suffusion solution Po2 were investigated in a study of the participation of oxygen in the regulation of blood flow. Diffusion gradients for oxygen were altered by changing the Po2 of a solution covering the surface of the hamster cheek pouch. As the solution P02 was raised from a low of 11 mm Hg,...

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The relative amplitudes and rates of increase of muscle blood flow (and O(2) delivery) and O(2) uptake responses determine the O(2) pressure within the muscle microvasculature (Pm(O(2))) across the rest-to-contraction transition. Skeletal muscle function is a primary determinant of pulmonary O(2) uptake kinetics; however, it has never been determined whether the dynamics of muscle Pm(O(2)) are ...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology

سال: 2008

ISSN: 0363-6135,1522-1539

DOI: 10.1152/ajpheart.00861.2007